Temporal dynamics of woolly mammoth genome erosion prior to extinction
More On Article
- New FWF Podcast 'Was Wir Wissen' Launched
- HEAS Members Awarded FWF Grant for a Project on “Beyond the Burial”
- HEAS Deputy Head Immo Trinks and HEAS Team Leader Wolfgang Neubauer Contribute to Paper on Durrington Walls Henge
- HEAS Deputy Head Publishes New Book on The Svinjarička Čuka Archaeological Site in Southern Serbia
- New “Balkan Fashion” Developing Through the Neolithization Process: The Ceramic Annulets of Amzabegovo and Svinjarička Čuka
Dehasque, M., Morales, H.E., Díez-del-Molino, D., Pečnerová, P., Chacón-Duque, J.C., Kanellidou, F., Muller, H., Plotnikov, V., Protopopov, A., Tikhonov, A., Nikolskiy, P., Danilov, G.K., Giannì, M., van der Sluis, L., Higham, T., Heintzman, P.D., Oskolkov, N., Gilbert, M.T.P., Götherström, A., van der Valk, T., Vartanyan, S., Dalén, L., 2024. Temporal dynamics of woolly mammoth genome erosion prior to extinction. Cell 187, 3531-3540.e3513.
Summary
A number of species have recently recovered from near-extinction. Although these species have avoided the immediate extinction threat, their long-term viability remains precarious due to the potential genetic consequences of population declines, which are poorly understood on a timescale beyond a few generations. Woolly mammoths (Mammuthus primigenius) became isolated on Wrangel Island around 10,000 years ago and persisted for over 200 generations before becoming extinct around 4,000 years ago. To study the evolutionary processes leading up to the mammoths’ extinction, we analyzed 21 Siberian woolly mammoth genomes. Our results show that the population recovered quickly from a severe bottleneck and remained demographically stable during the ensuing six millennia. We find that mildly deleterious mutations gradually accumulated, whereas highly deleterious mutations were purged, suggesting ongoing inbreeding depression that lasted for hundreds of generations. The time-lag between demographic and genetic recovery has wide-ranging implications for conservation management of recently bottlenecked populations.